Three Supplements That Reverse Aging

How to boost mitochondria, supplements to increase energy, resveratrol and SIRT1, what is NAD, NAD and aging, does B3 make NAD, what is nicotinamide adenine denucleotide

By David Blyweiss, M.D., Advanced Natural Wellness

November 21, 2016

  • More energy, strength and stamina is at your fingertips
  • Make your old cells young again
  • Three supplements that reverse aging

Energy… strength… stamina… vitality… enthusiasm…

These are all words you probably associate with youthfulness. And if they still describe you, that’s great! You’re doing something right.

But if words like weariness, weakness, disinterested and exhausted have taken over your vocabulary in recent years, your body’s energy factories might be aging faster than they should.

You see, about 90% of the energy needed by your body comes from tiny little power plants in your cells called mitochondria. They’re what fuel every cell in your body with energy.

But as you age, they become damaged and start running at the lowest level of functioning they can. They mutate and begin to malfunction. Eventually, they can no longer produce the energy necessary to do their job.

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When this happens, you start feeling older than you should. Health issues like heart disease, decreased strength, stroke and memory problems take up residence. Next thing you know, youth becomes a distant memory.

Well, how would like to make your old cells function at a younger level again?

It’s entirely possible… and not nearly as hard as you would expect.

Make Your Old Cells Young Again

I’ve long been an advocate of a natural antioxidant called resveratrol. It’s well-known for its anti-aging properties. I’m also fond of a similar compound called pterostilbene. It’s about four times more absorbable than resveratrol.

These two powerhouse nutrients turn on your anti-aging gene, SIRT1. This gene is the “master regulator” of mitochondrial replication. So when it’s activated, it helps your body produce more of those little energy factories and keep your cells powered up to youthful levels.

But today we know that there is another piece of the puzzle. And it could make the difference between describing yourself as “young and vibrant” versus “old and listless.”
It turns out that your body naturally produces an enzyme called “nicotinamide adenine denucliotide” (NAD for short). This enzyme is absolutely crucial to both SIRT1 and mitochondria!

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However, levels of it decline as you age.

This is a big problem, because if you don’t have enough NAD, SIRT1 loses the ability to do its job. Communication between cells gets scrambled, and mitochondria lose their ability to produce energy.

This is when signs of aging and disease start rearing their ugly heads.

However, if your NAD levels remain high enough to maximize the age-defying power of SIRT1, you can maintain youth and vibrancy throughout your lifetime.

And if you can maintain decent levels of new mitochondria, even better. You can help get rid of old malfunctioning mitochondria by fasting 13-14 hours which upregulates a process called autophagy and help make new ones with simple exercise. Combining these steps with some of the supplementation that follows is an excellent start to more energy.

Three Supplements to Reverse Rapid Aging

There are two ways to boost your NAD levels. And both of them work extremely well.

One way is with calorie restriction. This basically means cutting your calories by at least 20%. It works great to kick NAD and SIRT1 into action. But not everyone can manage to stick with it.

Thankfully, there’s an easier way. All you have to do is supplement with vitamin B3. Different names for B3 include niacin, niacinamide and nicotinamide. These are all precursors to NAD… your body can’t make it without them.

To make your old cells young again, raise your energy levels and help protect you from age-related health issues, I recommend that you take the following on a daily basis:

  • At least 50 mg. of resveratrol
  • 25 mg. of pterostilbene
  • 125 to 500 mg. of B3. Look for one that contains niacin, niacinamide or nicotinamide (ribose or monocleotide).

Now, you may get a niacin flush to start with. That’s why I recommend starting at 50 -100 mg. daily. Then, add an additional 100 mg. each week until you reach 500 mg. If you have problems with the flush, take an 81 mg. coated Bayer aspirin and it should help.


Ungvari Z, et al. Mitochondrial protection by resveratrol. Exerc Sport Sci Rev. 2011 Jul;39(3):128-32.

Cheng Y, et al. SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury. Apoptosis. 2016 Aug;21(8):905-16.

Cantó C, et al. Targeting SIRT1 to improve metabolism: all you need is NAD+? Pharmacol Rev. 2012 Jan; 64(1): 166–187.

Imai S, et al. It takes two to tango: NAD+ and sirtuins in aging/longevity control.

NPJ Aging and Mechanisms of Disease. 2016 Aug; no.16017.

Wang Y. Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation. Diabetes Metab J. 2014 Oct; 38(5): 321–329.

Longo VD, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 2015 Aug; 14(4): 497–510.

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